Abstract Search

ea0077oc4.1 | Adrenal and Cardiovascular | SFEBES2021

Development of [18F]AldoView as the first highly selective aldosterone synthase PET tracer for imaging of patients with Primary Hyperaldosteronism.

Sander Kerstin , Gendron Thibault , Cybulska Klaudia A. , Sirindil Faith , Zhou Jonhua , Kalber Tammy L. , Lythgoe Mark F. , Kurzawinski Tom R. , Brown Morris J. , Arstad Erik

Background: Inappropriately high aldosterone in patients with primary hyperaldosteronism (PHA) is due to increased aldosterone synthase (CYP11B2) activity. Selective in vivo imaging of overexpressed CYP11B2 in adrenals with positron emission tomography (PET) has not yet been achieved due to close homology of enzymes involved in aldosterone and cortisol (CYP11B1) synthesis.Aim: Synthesize a fluorine-18 labelled highly selective CYP11B2 inhibitor,...

0 shares

ea0081oc13.1 | Oral Communications 13: Adrenal and Cardiovascular Endocrinology 2 | ECE2022

Development of [18F]AldoView as the first highly selective aldosterone synthase PET tracer for imaging of patients with primary hyperaldosteronism

Sander Kerstin , Kurzawinski Tom , Gendron Thibault , Cybulska Klaudia , Sirindil Fatih , Zhou Junhua , Kalber Tammy , Lythgoe Mark , Brown Morris , Williams Bryan , Arstad Erik

Background: Inappropriately high aldosterone in patients with primary hyperaldosteronism (PHA) is due to increased aldosterone synthase (CYP11B2) activity. Selective in vivo imaging of overexpressed CYP11B2 in adrenals with positron emission tomography (PET) has not yet been achieved due to close homology of enzymes involved in aldosterone and cortisol (CYP11B1) synthesis.Aim: Synthesize a fluorine-18 labelled highly selective CYP11B2 inhibitor, [18...

0 shares

ea0094oc5.3 | Adrenal and Cardiovascular | SFEBES2023

Imaging of adrenal aldosterone synthase expression in patients with primary aldosteronism – a first-in-human study with [¹⁸F]aldoview PET-CT

Arstad Erik , Sander Kerstin , Kurzawinski Tom , Awais Ramla , Twyman Frazer , Pritchcard Dylan , Glaser Matthias , Edaan Esra , Sirindil Fatih , Buhidma Yazead , Shortman Robert , Dickson John , Anderson Cameron , Chung Teng-Teng , Abdel-Aziz Tarek , Brown Morris , Williams Bryan

Background: Primary aldosteronism (PA) is the most common potentially curable cause of secondary hypertension and is a risk factor for cardiovascular morbidity and mortality. For patients with unilateral disease adrenalectomy can be curative. However, PA remains substantially underdiagnosed due the complex diagnostic pathway required to identify patients with unilateral disease, and the difficulties in accurate lateralization of the affected adrenal gland. Spe...

0 shares

Endocrine Abstracts

Development of [18F]AldoView as the first highly selective aldosterone synthase PET tracer for imaging of patients with Primary Hyperaldosteronism.

Development of [18F]AldoView as the first highly selective aldosterone synthase PET tracer for imaging of patients with primary hyperaldosteronism

Imaging of adrenal aldosterone synthase expression in patients with primary aldosteronism – a first-in-human study with [¹⁸F]aldoview PET-CT

BiosciAbstracts

Endocrine Abstracts

Development of [18F]AldoView as the first highly selective aldosterone synthase PET tracer for imaging of patients with Primary Hyperaldosteronism.

Development of [18F]AldoView as the first highly selective aldosterone synthase PET tracer for imaging of patients with primary hyperaldosteronism

Imaging of adrenal aldosterone synthase expression in patients with primary aldosteronism – a first-in-human study with [18F]aldoview PET-CT

BiosciAbstracts

Imaging of adrenal aldosterone synthase expression in patients with primary aldosteronism – a first-in-human study with [¹⁸F]aldoview PET-CT